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Some Things You Might Not Know About Pomegranates

One simple Pomegranate a Day:

  • 12% of the Recommended Dose of Rich Soluble Dietary Fibers
  • Abundant Anti-Oxidants (Punicalagin buried in Pomegranates)
  • 17% of the 100g Daily Requirements of Vitamin-C
  • Resistance against infection and boosting of the immune system

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Some other interesting and more technical facts and studies we’ve found about pomegranates:

Consumption of polyphenol plants may slow aging and associated diseases.

Slowing aging is a widely shared goal. Plant-derived polyphenols, which are found in commonly consumed food plants such as tea, cocoa, blueberry and grape, have been proposed to have many health benefits, including slowing aging. In-vivo studies have demonstrated the lifespan-extending ability of six polyphenol-containing plants. These include five widely consumed foods (tea, blueberry, cocoa, apple, pomegranate) and a flower commonly used as a folk medicine (betony). These and multiple other plant polyphenols have been shown to have beneficial effects on aging-associated changes across a variety of organisms from worm and fly through rodent and human.

Uysal U, Seremet S, Lamping JW, Adams JM, Liu DY, Swerdlow RH, Aires DJ.
Division of Dermatology, University of Kansas School of Medicine, 3901 Rainbow Boulevard Mailstop 2025, Kansas City, KS, 66207, USA. daires@kumc.edu.
Curr Pharm Des. 2013 Feb 19. [Epub ahead of print]

Influence on longevity of blueberry, cinnamon, green and black tea, pomegranate, sesame, curcumin, morin, Pycnogenol, quercetin and taxifolin fed isocalorically to long-lived, outcrossed mice.

Phytonutrients reportedly extend the lifespan of C. elegans, Drosophila, and mice. We tested extracts of blueberry, pomegranate, green and black tea, cinnamon, sesame, and French maritime pine bark (Pycnogenol and taxifolin), as well as curcumin, morin, and quercetin for their effects on the lifespan of mice. While many of these phytonutrients reportedly extend the lifespan of model organisms, we found no significant effect on the lifespan of male, F1 hybrid mice, even though the dosages used reportedly produce defined therapeutic endpoints in mice. The compounds were fed beginning at 12 months of age. The control and treatment groups were isocaloric with respect to one another. A 40% calorically restricted and other groups not reported here did experience lifespan extension. Body weights were unchanged relative to controls for all but two supplemented groups, indicating most supplements did not change energy absorption or utilization. Tea extracts with morin decreased weight, while quercetin, taxifolin, and Pycnogenol together increased weight. These changes may be due to altered locomotion or fatty acid biosynthesis. Published reports of murine lifespan extension using curcumin or tea components may have resulted from induced caloric restriction. Together, our results do not support the idea that phytonutrient-antioxidants and anti-inflammatories are potential longevity therapeutics, even though consumption of whole fruits and vegetables is associated with enhanced health- and lifespan.

Spindler S, Mote PL, Flegal JM, Teter B.
University of California, Riverside, Biochemistry, 1463 Boyce Hall, Riverside, California, United States, 92521, 9518273597, 4137149176; spindler@ucr.edu.
Rejuvenation Res. 2013 Feb 24. [Epub ahead of print]

Pomegranate seed extract attenuates (weakens) chemotherapy-induced liver damage in an experimental model of rabbits.

Yildirim NC, Kandemir FM, Ceribasi S, Ozkaraca M, Benzer F.
Tunceli University, Faculty of Engineering Department of Environmental Engineering Tunceli Turkey nurancyildirim@gmail.com.
Cell Mol Biol (Noisy-le-grand). 2013 Feb 2;59 Suppl:OL1842-7

The aim of this study was to determine whether antioxidant pomegranate seed extract (PSE) has a preventive effect on cisplatin—induced hepatotoxicity. Rabbits were divided into 3 groups (n=6):1—Control group (0.9 % saline. i.p) 2—Cisplatin group (a single dose of cisplatin (5 mg/kg, i.p) 3— A single dose of cisplatin (5 mg/kg, i.p) + PSE (250 mg/kg/day, i.p) for 6 consecutive days before and 6 consecutive days after a single intraperitoneal dose of 5 mg/kg body weight cisplatin. Liver function enzymes and malondialdehyde (MDA) levels were found significantly higher in cisplatin group compared to control. Liver catalase (CAT) and glutathione peroxidase (GSH—PX) activities decreased with cisplatin treatment but glutathione (GSH) level was increased. In cisplatin + PSE group, liver function enzyme activities and tissue MDA levels were found lower than cisplatin group. PSE ameliorated cisplatin—induced pathological changes. As a result it was demonstrated that PSE has protective effects against cisplatin hepatotoxicity in rabbit.

Efficacy of Punica granatum L. hydroalcoholic extract on properties of dyed hair exposed to UVA radiation.

Dario MF, Pahl R, de Castro JR, de Lima FS, Kaneko TM, Pinto CA, Baby AR, Velasco MV.
School of Pharmaceutical Sciences of University of São Paulo, 580 Prof. Lineu Prestes Avenue, Bl-13/15, São Paulo, SP, Brazil.
J Photochem Photobiol B. 2013 Jan 5. pii: S1011-1344(13)00002-X. doi:
10.1016/j.jphotobiol.2012.12.011. [Epub ahead of print]

The solar radiation promotes color fading of natural and dyed hair by free radical generation, which oxidize the pigments, and it has been proposed the incorporation of antioxidants in order to reduce the alterations of hair color. Due to its high content of polyphenols and tannins, which are potent antioxidants, the hydroalcoholic extract of Punica granatum L. (pomegranate) was used in this research. Hair care formulations containing pomegranate extract were applied to red dyed hair tresses, and these were exposed to UVA radiation. Non-ionic silicone emulsion presenting color protection properties were also used for comparison purpose between the results obtained with different treatments, including silicone in combination with the pomegranate extract. The pomegranate extract at 5.0% and 10.0%w/w was effective in preventing the hair color fading in 37.6% and 60.8%, respectively, but the association of hydroalcoholic extract and non-ionic silicone emulsion is not encouraged. Mechanical properties were not affected by UVA radiation, since significant differences in breaking strength were not observed. Considering the conditions which the tresses have been exposed, it was concluded that the pomegranate extract at 10.0% w/w in hair care formulations are effective in reducing color fading of red dyed hair.
Copyright © 2013 Elsevier B.V. All rights reserved.

Antiproliferative effects of pomegranate extract in MCF-7 breast cancer cells are associated with reduced DNA repair gene expression and induction of double strand breaks.

Mol Carcinog. 2013 Jan 28. doi: 10.1002/mc.21995. [Epub ahead of print]
Shirode AB, Kovvuru P, Chittur SV, Henning SM, Heber D, Reliene R.
Department of Environmental Health Sciences, University at Albany, State University of New York, Albany, New York; Cancer Research Center, University at Albany, Rensselaer, New York.

Pomegranate extract (PE) inhibits the proliferation of breast cancer cells and stimulates apoptosis in MCF-7 breast cancer cells. While PE is a potent antioxidant, the present studies were conducted to examine the mechanisms of action of PE beyond antioxidation by studying cellular and molecular mechanisms underlying breast tumorigenesis. PE inhibited cell growth by inducing cell cycle arrest in G(2) /M followed by the induction of apoptosis. In contrast, antioxidants N-acetylcysteine and Trolox did not affect cell growth at doses containing equivalent antioxidant capacity as PE, suggesting that growth inhibition by PE cannot solely be attributed to its high antioxidant potential. DNA microarray analysis revealed that PE downregulated genes associated with mitosis, chromosome organization, RNA processing, DNA replication and DNA repair, and upregulated genes involved in regulation of apoptosis and cell proliferation. Both microarray and quantitative RT-PCR indicated that PE downregulated important genes involved in DNA double strand break (DSB) repair by homologous recombination (HR), such as MRE11, RAD50, NBS1, RAD51, BRCA1, BRCA2, and BRCC3. Downregulation of HR genes correlated with increased levels of their predicted microRNAs (miRNAs), miR-183 (predicted target RAD50) and miR-24 (predicted target BRCA1), suggesting that PE may regulate miRNAs involved in DNA repair processes. Further, PE treatment increased the frequency of DSBs. These data suggest that PE downregulates HR which sensitizes cells to DSBs, growth inhibition and apoptosis. Because HR represents a novel target for cancer therapy, downregulation of HR by PE may be exploited for sensitization of tumors to anticancer drugs. © 2013 Wiley Periodicals, Inc.
Copyright © 2013 Wiley Periodicals, Inc.

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